An inherited predisposition allele promotes gastric cancer via enhancing deubiquitination-mediated activation of epithelial-to-mesenchymal transition signaling.

The results showed that elevated expression levels of USP47 are markedly correlated with increased tumor invasiveness, lymph node metastasis, and advanced tumor stages in the TCGA and Ooi GSE15459 datasets ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=gse15459 ), with a borderline significance in high-grade tumors ( 29 ) ( Figure 1, F–I ).

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