Memory-promoting function of miR-379-5p attenuates CD8<sup>+</sup> T cell exhaustion by targeting immune checkpoints.

Moreover, high miR-379-5p expression combined with CD8 + T cell infiltration was significantly associated with improved overall survival in BRCA (HR=0.533, p=0.00463) and CESC (HR=0.513, p=0.00484), with a weak trend toward significance in SKCM (HR=0.61, p=0.304) ( figure 2D , online supplemental figure 3 ), suggesting that miR-379-5p-mediated T cell infiltration enhances antitumor immunity and improves outcome. miR-379-5p directly targets the immune checkpoints TIM3 and TIGIT To investigate the mechanism linking miR-379-5p with T cell-mediated antitumor immunity, we analyzed the interaction between miR-379-5p and 23 major immune checkpoints using miRTarBase annotations and 12 prediction tools for potential miRNA-target gene interactions.

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