Sex-specific attenuation of photoreceptor degeneration by reserpine in a rhodopsin P23H rat model of autosomal dominant retinitis pigmentosa.

To further understand upregulation of proteostasis network, we checked two key factors p62 (Sqstm1) and Nrf2 (Nfe2l2) and identified robust overexpression in the former while the latter did not show significant response despite an increasing trend ( Figure 6G , Figure 6—figure supplement 1E ).

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