Both asparagine and proline are required to decrease <i>Sestrin2</i> mRNA levels via ATF4 reduction and regulate collagen type I alpha 1 chain production and the proliferation of quiescent RI?T hepatic stellate cells.

Biomed Rep · 2025 · PMC12001209 · PMID 40247930

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an increasing trendno p-value reported

A meta-analysis showed that the global prevalence rate of advanced liver fibrosis in the general population is 3.3% (95% CI, 2.4-4.2%), with an increasing trend observed in recent years ( 1 ).

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Both asparagine and proline are required to decrease &lt;i&gt;Sestrin2&lt;/i&gt; mRNA levels via ATF4 reduction and regulate collagen type I alpha 1 chain production and the proliferation of quiescent RI?T hepatic stellate cells.

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Both asparagine and proline are required to decrease <i>Sestrin2</i> mRNA levels via ATF4 reduction and regulate collagen type I alpha 1 chain production and the proliferation of quiescent RI?T hepatic stellate cells.