Tutorial on Conditional Simulations With a Tumor Size-Overall Survival Model to Support Oncology Drug Development.

CPT Pharmacometrics Syst Pharmacol · 2025 · PMC12001264 · PMID 39985154

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a numerical trendno p-value reported

In other words, these simulations would have showed at the interim data cut that it is unlikely that the final OS dataset would show a numerical trend in the hazard ratio favoring the combination therapy over the chemotherapy alone.

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