Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.

Proc Natl Acad Sci U S A · 2025 · PMC12002227 · PMID 40127276

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hedged sentence

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = 4.63 × 10 −19actually significant

DNM’s showed no enrichment of synonymous or tolerated missense variants (“T-mis”), but highly significant enrichment for both LOF (1.49-fold enriched, P = 4.63 × 10 −19 ) and damaging missense (D-mis) DNMs (1.35-fold enriched, P = 1.24 × 10 −13 ) ( SI Appendix , Table S4A ).

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