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Optimization of mtDNA-targeted platinum TALENs for bi-directionally modifying heteroplasmy levels in patient-derived m.3243A>G-iPSCs.

Mol Ther Nucleic Acids · 2025 · PMC12002989 · PMID 40242044

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a decreasing trendno p-value reported
However, the differences in heteroplasmy levels between mp[PLW6NM-ELD/JR-KKR]-applied and mp[PLW6NM-ELD/JR-ELD]-applied cells exhibited a decreasing trend after 25 days ( Figure 5 B).

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