<i>CR1</i> variants contribute to FSGS susceptibility across multiple populations.

16 In the study conducted by Opi et al., it was noted by the authors that the opposite concomitant effect of the McC b (rs17047660) allele on the development of severe malaria was of only nominal borderline significance, despite being under significant strong positive selection (iHS<−2.0). 16 At first glance, the association with severe malaria and significant positive McC b selection are discouraging, but this may explain the linkage of negative and protection haplotypes to each other.

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