Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations.

The results showed that RA-FLS exhibited a decreasing trend in mean-square displacement (vector leveling method from the first to current displacement observation point, averaged over all cells in the well) under different TPL concentrations as observation time increased ( Figure 2A ).

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