The histone chaperone Spn1 preserves chromatin protections at promoters and nucleosome positioning in open reading frames.

Mapping the sequenced fragments 80–170 bp over genes ranked with the NET-seq data and generating difference plots shows a slight trend in nucleosome positioning defects between the lowest and highest quartiles, especially at the promoter-proximal nucleosome positions ( Supplementary Fig. 13b, File 1 ).

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We next performed gene set enrichment analysis of genes belonging to groups 1–4 and found highly significant overlap with terms related to metal ion transport, glycolysis, and ribosome biogenesis, among others ( Supplementary Fig. 18d, File 1 ).

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