Long-term outcomes after revascularization surgery for adult moyamoya disease: Protocol for systematic review and meta-analysis.

For studies with highly significant heterogeneity (I2 > 75%), we will conduct a manual review to identify potential issues such as small sample size, study design flaws, or poor data quality.

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The long-term follow-up results after combined revascularization surgery also indicated a decreasing trend in cerebral blood flow in the territory of the middle cerebral artery (MCA) in the operated hemispheres as the follow-up period progresses [ 21 ].

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