The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway.

Front Pharmacol · 2025 · PMC12006087 · PMID 40255567

Europe PMC DOI

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an increasing trendp > 0.05actually significant

The AM group exhibited a significant decrease in WBC levels compared to the AC group ( p < 0.05), while the levels of RBC, HGB, and PLT showed an increasing trend without reaching statistical significance ( p > 0.05).

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a decreasing trendno p-value reported

The results of this experiment showed that the proportions of lymphocytes and T, Th, naïve Tc, naïve Th and effector Tc cells decreased significantly in naturally aging rats showed a decreasing trend, while the proportions of Treg, Tc, memory Tc and memory Th cells increased significantly, which is consistent with the dysregulation of cellular subsets in the elderly.

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