Suppressed intestinal secondary bile acids in moxifloxacin-induced hyperglycemia: studies in normal and diabetic GK rats.

Front Pharmacol · 2025 · PMC12006139 · PMID 40255568

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a decreasing trendno p-value reported

After 14 days, a slight upward trend of total BAs was observed in CT + MFLX group (10%↑), whereas a decreasing trend persisted in GK + MFLX group (30%↓) ( Supplementary Figure S2A ).

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an observed trendno p-value reported

In our study, MFLX treatment resulted in downregulation of intestinal FXR and a reduction in serum FGF15 levels, accompanied by an observed trend of hepatic CYP7A1 upregulation in GK rats.

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