55 Our experiments showed that pretreating cells with C22 did not lead to a significant change in tunicamycin- and thapsigargin-induced UPR ER , only resulting in a nonsignificant trend to slightly attenuate ATF6A and ATF4 expression in thapsigargin-treated cells ( Supplementary Figure S5F–J ).
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Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation.
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