Molecular and phenotypic characterization of 5-FU resistant colorectal cancer cells: toward enrichment of cancer stem cells.

Cancer Cell Int · 2025 · PMC12008981 · PMID 40251609

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Overlap of differentially expressed genes in CRC cell lines in response to 5-FU treatment Analysis of common differentially expressed genes in both parental and 5-FU-exposed subpopulations of Caco2 and HT-29 cells revealed a highly significant overlap with enriched pathways in the KEGG database, including MicroRNAs in cancer, signaling pathways regulating pluripotency of stem cells, and Proteoglycans in cancer (Table 3 ).

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