Alpha-smooth muscle actin-expressing dermal sheath cells are a major cellular contributor to heterotopic subcutaneous ossifications in a mouse model of Albright hereditary osteodystrophy.

JBMR Plus · 2025 · PMC12009542 · PMID 40256763

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We detected a markedly significant expansion of dermal Osterix+ cell populations within Gnas E1+/−;Osx-mCherry mice at 24 wk ( Figure 2C-E ) when compared to littermate Osx-mCherry controls within skin regions without radiographically detectable SCOs.

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