highly significantP < 0.001
Repeated measures ANOVA indicated highly significant effects of dose ( F 3,12 = 51.40, P < 0.001, partial η 2 = 0.93), chemical ( F 5,20 = 12.41, P < 0.001, partial η 2 = 0.76), and dose x chemical interaction ( F 15,60 = 26.13, P < 0.001, partial η 2 = 0.87).