borderline significantP = 1.1 × 10 −6
Given that the statistical power in the top1 datasets was relatively low due to the small sample size (4017 individuals), we investigated the p-values of the two eGFRcrecys-specific signals, and found that one (rs9532933 on chromosome 13) was borderline significant for the other two traits ( P = 1.1 × 10 −6 for creatinine and 3.0 × 10 −7 for cystatin C, Table S7 ), while the other (rs116542696 on chromosome 20) was borderline significant only for cystatin C ( P = 0.20 for creatinine and 1.3 × 10 −7 for cystatin C, Fig. 5d–f , Table S7 ), suggesting that these signals are likely not eGFRcrecys-specific, but shared with at least one for the two biomarkers.