Synergistic chemo-immunotherapy for osteosarcoma via a pH-responsive multi-component nanoparticle system.

The second-order polynomial regression model was applied to determine the relationship between the independent variables and the response variable: Y = − 66.25 + 31.74 X 1 + 20.51 X 2 + 29.15 X 3 + 49.40 X 4 − 6.03 X 1 2 − 1.94 X 2 2 − 11.76 X 3 2 − 12.18 X 4 2 The ANOVA results for the model ( Table 6 ) indicated that this model was highly significant ( P < 0.0001).

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