Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma.

Moreover, Tumour Immune Dysfunction and Exclusion (TIDE) analysis 25 of bulk RNA-seq dataset from The Cancer Genome Atlas (TCGA) also demonstrated highly significant associations of HDAC1 / 2 / 3 high patients with predicted ICB non-responsiveness ( figure 1F ), further evidenced by the higher TIDE, T cell exclusion and myeloid-derived suppressor cell (MDSC) gene signatures ( figure 1G ).

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