Investigating colour vision and its structural correlates 15 years following a first demyelinating event.

J Neurol Neurosurg Psychiatry · 2025 · PMC12015080 · PMID 39266283

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

borderline significantp=0.053so close (0.05 < p ≤ 0.1)

Unaffected eyes showed borderline significant thinner mGCIPL in SPMS compared with CIS (difference −11.45 μm (SE 4.74), p=0.053 SPMS vs CIS) but no significant difference between RRMS and CIS or between SPMS and RRMS.

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borderline significanceno p-value reported

Thinner GCIPL thicknesses were also seen in patients with SPMS with borderline significance compared with CIS in keeping with previous studies 32 , 34 and were associated with worsening metrics for LCVA and FM 100 Hue colour vision. pRNFL was only significantly associated with colour vision and there were no significant differences between MS phenotypes, suggesting that mGCIPL is a more reliable OCT marker of disease progression following a first demyelinating episode than pRNFL.

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