Aspirin prevents metastasis by limiting platelet TXA<sub>2</sub> suppression of T cell immunity.

Accordingly, we observed highly significant enrichment in the expression of genes upregulated in memory versus naive CD8 + T cells in TXA 2 analogue-treated Arhgef1- deficient cells compared with wild-type cells 32 (Fig. 4b , Extended Data Fig. 9 and Supplementary Tables 3 – 5 ).

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