Prediabetes Associates with Matrix Metalloproteinase-8 Activation and Contributes to the Rapid Destruction of Periodontal Tissues.

Additionally, a potential aMMP-8–periodontitis–prediabetes/diabetes connection has been suggested earlier, implying a positive association between aMMP-8, and both periodontopathogenic dysbiotic proteolysis and prediabetes, as well as with periodontitis grade. 25 There is also an increasing trend in MMP-8 protein expression levels in patients suffering from either periodontal disease and diabetes or both. 26 Diabetes/hyperglycemia increases the local periodontal inflammation and related inflammatory biomarker levels in periodontal tissues. 27 These heightened inflammatory responses thro

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