Association of Phthalate Exposure with Respiratory and Allergic Symptoms and Type 2 and Non-Type 2 Inflammation: The Hokkaido Study.

Considering the non-T2 biomarker ANC, although the mixture model showed a positive trend, individual models were not significant.

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Furthermore, our previous report on 7-year-old Japanese children found a stable phthalate trend 29 and an increasing trend in phthalate alternative plasticizers from samples collected from 2012 to 2017. 36 These findings suggest that Japan’s regulatory measures 37 may have contributed to the observed decline of phthalate exposure in the current study, along with the market shift toward alternative plasticizers.

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