Sustainable approach for synthesis of new coumarin-linked Schiff bases in DABCO-based ionic liquid and their identification as aldose reductase inhibitors.

Among 4′′-substituted halogenated analogues ( 6, 9 and 11 ), excellent yields were obtained with a decreasing trend moving from bromo- to fluoro-substituted analogue. 97% Yield was acquired for bromo-substituted analogue ( 11 ), 93% chloro-substituted ( 9 ) and 79% yield for p -flouro analogue ( 6 ). 2′′-Substituted halogenated compounds ( 7 and 10 ) showed relatively better results (> 90% yields) as compared to compound 8 with chloro-substitutent at 3′′-position, which gave 87% yield.

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