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Trends in burden and mortality of congenital birth defects in G20 countries (1990-2021) and predictions for 2022-2040.

BMC Pregnancy Childbirth · 2025 · PMC12023674 · PMID 40281466

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a decreasing trendno p-value reported
an increasing trendno p-value reported
Specifically, an APC or AAPC < 0 indicates a decreasing trend in disease burden, while an APC or AAPC > 0 signifies an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.