Oral Intake of <i>Streptococcus thermophilus</i> iHA318 Mitigates Dry Eye Symptoms in a Randomized Clinical Study.

Specifically, participants in the probiotic group exhibited a significant increase in TBUT in the right eye (pretreatment: 2.95 ± 0.19 s, post-treatment: 4.22 ± 0.39 s; p = 0.023) and a notable trend towards improvement in the left eye (pretreatment: 3.51 ± 0.35 s, post-treatment: 4.30 ± 0.51 s; p = 0.105), with a significant increase in the total average TBUT (pretreatment: 3.23 ± 0.22 s, post-treatment: 4.26 ± 0.41 s; p = 0.015).

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In the placebo group, there was an increasing trend in tear volume for both the right eye (pretreatment: 7.29 ± 0.87 mm; post-treatment: 9.50 ± 0.99 mm; p value: 0.004) ( Figure 2 A) and the left eye (pretreatment: 5.97 ± 0.39 mm; post-treatment: 9.33 ± 1.22 mm; p value: 0.006) ( Figure 2 B).

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