Hypothermia Shifts Neurodegeneration Phenotype in Neonatal Human Hypoxic-Ischemic Encephalopathy but Not in Related Piglet Models: Possible Relationship to Toxic Conformer and Intrinsically Disordered Prion-like Protein Accumulation.

Cells · 2025 · PMC12025496 · PMID 40277911

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Damage to PCM1 might be significant to neuro- and glio-degeneration after HI because PCM1 organizes the cytoskeleton and is critical for dendrite stability and neurite elaboration [ 129 , 130 ], possibly driving the collapse of neuronal dendrites and destruction of oligodendrocyte processes and myelination after HI.

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