Lithium Treatment Increases FKBP5 Protein but Not mRNA Expression in the Pituitary Gland of Depressive-like Rats.

During short- and long-term lithium administration, we did not observe significant differences between groups ( Figure 5 B,C); however, the corticosterone levels showed a decreasing trend in the rats receiving lithium for 42 days in comparison to those receiving the vehicle ( p = 0.06) ( Figure 5 C) 4.

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After lithium treatment, the changes were not significant between treated and non-treated rats, although they showed an increasing trend in distance travelled upon lithium treatment.

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