Barely Significant
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Comprehensive Aerodynamic and Physicochemical Stability Evaluations of Nanocrystal-Based Dry Powder Inhalers: The Role of Mannitol and Leucine in Enhancing Performance.

Pharmaceutics · 2025 · PMC12030377 · PMID 40284431

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highly significantno p-value reported
Another study found a highly significant and positive impact of leucine on enhancing the FPF of spray-dried mannitol particles [ 62 ].

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