Finally, cohort analysis reveals a U-shaped pattern, with higher risks in 1950’s cohorts (RR: 1.102; 95%CI 1.038–1.169), while younger cohorts demonstrate a decreasing trend, as observed for 2015’s cohort (RR: 0.660; 95%CI 0.553–0.788)—Tables 1 , 2 , 3 , and Fig. 2 .
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