H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma.

Epigenetics Chromatin · 2025 · PMC12032731 · PMID 40287708

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an overall trendno p-value reported

The prominent upregulation of extracellular matrix-related genes, despite an overall trend of repression in other developmental pathways, hints at a dual role for K27M.

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