Blockade of TIGAR prevents CD8<sup>+</sup> T cell dysfunction and elicits anti-AML immunity.

Cancer Immunol Immunother · 2025 · PMC12033161 · PMID 40285889

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0690

boldest claim

The sentences

a decreasing trendP = 0.069so close (0.05 < p ≤ 0.1)

Compared with TIGAR WT, TIGAR KO showed a decreasing trend in spleen infiltration in AML mice (AML proportion: 36.7% vs. 26.7%, P = 0.069, Fig. 2 C, D).

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highly significantno p-value reported

A volcano plot was generated to visualize the results, and a violin plot was used to illustrate the expression and distribution of the highly significant gene TIGAR between the high and low expression CD8 + T cell groups.

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