Electrostatic Anchoring in RNA-Ligand Design─Dissecting the Effects of Positive Charges on Affinity, Selectivity, Binding Kinetics, and Thermodynamics.

J Med Chem · 2025 · PMC12035807 · PMID 40191889

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a slight trendno p-value reported

For both compound series, SAM, SAH, compounds 1 and 2, and preQ 0 , preQ 1 , only a slight trend that a higher number of positive charges can lead to enhanced association rates, and thus affinity to the RNA targets, was observed.

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