Furthermore, ELISA detection revealed the significant upregulation of TNF-α expression and marginally significant upregulation of CRP expression but no significant increase in the IL-6 concentration after PWSDS (Fig. 3 B).
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A Novel Mouse Model of Depression: Advantages in Immune Research and Clinical Translation.
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The PWSDS-exposed mice exhibited the elevated expression of serum proinflammatory cytokines and abnormal microglial activation, especially in the dHP The expression of serum inflammatory factors in PWSDS-exposed mice generally tended to increase, as TNF-α and CRP mRNA expression were significantly upregulated after PWSDS stress and the change in IL-6 mRNA expression showed marginal significance (Fig. 3 A).