Barely Significant
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Genetic evidence from Mendelian randomization links CD40 levels to increased risk of estrogen receptor-positive breast cancer.

Sci Rep · 2025 · PMC12037882 · PMID 40295650

Europe PMCDOI
1
hedged sentence
0.0490
closest p · 1.0× alpha
0.0490
boldest claim

The sentences

borderline significantp = 0.049actually significant
Reverse MR analyses were also performed to examine if BC influences CD40/CD40L levels.A borderline significant association was found between CD40 levels and overall BC risk (IVW OR 1.027, 95% CI 1.000–1.054, p = 0.049), with a more robust association observed for ER-positive BC (OR 1.048, 95% CI 1.016–1.082, p = 0.003).

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