Associations between five indicators of epigenetic age acceleration and all-cause and cause-specific mortality among US adults aged 50 years and older.

Clin Epigenetics · 2025 · PMC12038942 · PMID 40301953

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an increasing trendno p-value reported

When used as categorical variables, EAA measured by DNAmAges also showed a stepwise increasing association with the risk of all-cause and non-cardiovascular mortality ( P -value for trend < 0.05), but in terms of cardiovascular mortality risk, only AAGrimAge and AAGrimAge2 were found to show an increasing trend with the risk of cardiovascular mortality ( P -value for trend = 0.026 and P-value for trend = 0.006).

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