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The autocrine motility factor receptor delays the pathological progression of Alzheimer's disease via regulating the ubiquitination-mediated degradation of APP.

Alzheimers Res Ther · 2025 · PMC12039061 · PMID 40301979

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an obvious trendno p-value reported
Likewise, AMFR protein level showed an obvious trend of reduction during aging, and the 8-month-old APP/PS1 mice exhibited a significant decrease compared to the age-matched WT mice, which indicated a potential role of AMFR in AD progression (Fig. 1 B).

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