Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in <i>Pseudomonas aeruginosa</i> isolates in a tertiary hospital.

An increasing trend in C/T resistance after the drug reintroduction (10.0% in Period C) was observed, warning about a return of resistance, at a much faster pace than the original decline, as also reported in the literature ( De Gelder et al., 2004 ; Levin et al., 1997 ; Austin et al., 1999 ; Heinemann et al., 2000 ).

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