A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration.

Development · 2025 · PMC12045596 · PMID 40013494

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highly significantno p-value reported

GSEA analyses for hallmarks comparing the adult and fetal spheroid transcriptomes, revealed highly significant upregulation of genes implicated in epithelial-mesenchymal transition (61 genes; FDR q value e −51 ), activation of the NFkB pathway (58 genes; FDR q value e −48 ) or inflammation (42 genes; FDR q value e −28 ), and stimulation by interferon gamma (39 genes; FDR q value e −25 ) ( Table S3 ).

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