Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes.

In PPGL tumors from patients without CCHD of the TCGA, EPAS1 was the gene with the third largest signal of positive selection (after HRAS and NF1 ) and marginally significant (dN/dS = 110; q = 0.1; Supplementary Table S2).

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