Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.

The present study revealed an increasing trend in MD values in the Aβ‐positive group compared to the Aβ‐negative group in most layers, particularly in layers II/III.

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We found that, after controlling for covariates of age, sex, cortical thickness, PMI, and FT, Aβ‐positive cases tended to exhibit higher MD values compared to Aβ‐negative cases in all layers ( p < 0.05 for layers II/III and marginally significant in layer IV/V/VI due to the small sample size) (Table 3 ).

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