Data were evaluated using Student’s t -test and were expressed as a mean ± SD; * p ≤ 0.05 was considered statistically significant, ** p ≤ 0.01 very significant, and *** p ≤ 0.001 highly significant.
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Therapy-induced senescence of glioblastoma cells is determined by the p21<sup>CIP1</sup>-CDK1/2 axis and does not require activation of DREAM.
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