STMN1-IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights.

Mol Med · 2025 · PMC12049776 · PMID 40319242

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a decreasing trendno p-value reported

Immunohistochemistry analysis showed that the expression of p16, p21, MMP3, and STMN1 increased with age and was significantly higher in NP cells of 20-month-old rats, while the expression of Collagen II showed a decreasing trend (Fig. 2 C–D).

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