highly significantp < 0.05
and statistical significance is reported as highly significant using * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
and statistical significance is reported as highly significant using * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.