Hydroxychloroquine increases the exposure of methotrexate in plasma and red blood cells: a pharmacokinetic interaction study in rats in vivo.

Front Pharmacol · 2025 · PMC12059348 · PMID 40342994

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0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

an increasing trendP = 0.056so close (0.05 < p ≤ 0.1)

Results In the single-dose group, the CTG exhibited a significant increase in the RBC MTX Cmax compared to the MTG (P = 0.023), whereas the AUC of RBC MTX showed an increasing trend (P = 0.056).

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