A mechanism of global gene expression regulation is disrupted by multiple disease states and drug treatments.

PLoS One · 2025 · PMC12061403 · PMID 40341320

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failed to reach significanceno p-value reported

A similar shift was observed for one study ( GSE111175 , Fig 6d ) of autism spectrum disorder (ASD), but two other ASD studies ( GSE25507 /42133, Fig 6e , f ) failed to reach significance, even if their profiles trended in the same direction.

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highly significantno p-value reported

In vitro cellular knockdown data ( GSE24345 , Fig 6a ) [ 8 ], when reanalysed, demonstrated a highly significant C + A- global transcriptome change – a genetic counterpart to the earlier nucleobase analogue drug treatments.

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