Is a thermal pulsation system (LipiFlow) effective as a standalone treatment for meibomian gland dysfunction and dry eye? A systematic review and meta-analysis.

Ther Adv Ophthalmol · 2025 · PMC12065985 · PMID 40352434

Europe PMC DOI

hedged sentence

0.0570

closest p · 1.1× alpha

0.0570

boldest claim

The sentences

marginal significancep = 0.057so close (0.05 < p ≤ 0.1)

The “Warm Compression” subgroup (three studies) demonstrated the highest effect size (SMD = 0.305, 95% CI: −0.009 to 0.619), with marginal significance ( p = 0.057).

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