Inhibition of Purine Metabolism Promotes the Differentiation of Neuroblastoma Driven by MYCN.

We further analyzed the human brain development (BrainSpan atlas) by the R2 data platform and revealed that there is an overall trend of a gradual decrease in purine enzyme gene expression from 8 weeks of age after fertilization to the prenatal period and that the purine enzyme gene expression levels are significantly lower at the postnatal stage than those at the prenatal period (Figure 2G , Figure S5A–D ).

also in 4,871 other papers