Genomic analysis of progenitors in viral infection implicates glucocorticoids as suppressors of plasmacytoid dendritic cell generation.

Proc Natl Acad Sci U S A · 2025 · PMC12067256 · PMID 40294270

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Consistent with our transcriptomic analysis, we observed that while the percentage and numbers of pre-DCs were significantly enhanced after ARM infection and exhibited an increasing trend after Cl13 infection ( Fig. 3 D ), the frequency and absolute number of pre-pDCs were significantly reduced and barely detectable after both ARM and Cl13 infections ( Fig. 3 E ).

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